Stabilizatoriaus parinkimas ekstemporaliai gaminamai sieros suspensijai ir kokybės tyrimas

Sereičikienė, Jolita

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Stabilizatoriaus parinkimas ekstemporaliai gaminamai sieros suspensijai ir kokybės tyrimas

Sereičikienė, Jolita

URI: http://dspace.kaunokolegija.lt//handle/123456789/381

Data: 2018

Santrauka:

Baigiamajame bakalauro darbe atskleidžiamas stabilizatoriaus parinkimas ekstemporaliai gaminamai sieros suspensijai ir kokybės tyrimas Išnagrinėjus mokslinę literatūrą bei atlikus duomenų analizę buvo pateiktos išvados. Darbą sudaro įvadas. Darbas suskirstytas į du skyrius: literatūros analizę, kurios paskirtis - metodologiškai pagrįsti tiriamąją darbo dalį ir tiriamojo darbo dalis, kurioje pateikta tyrimo metodika ir rezultatų analizė. Darbe pateiktos darbo išvados, literatūros sąrašas, santraukos lietuvių ir užsienio kalbomis. Darbo apimtis 47 puslapiai, pateikta 7 lentelės, 14 paveikslų, 1 priedas, panaudotos literatūros sąrašą sudaro 30 mokslinių publikacijų, tarp jų publikacijos užsienio kalba.

Description:

Aim of the work: To determine the appropriate stabilizer for liquid sulphur suspension and to simulate a high-quality stable sulphur suspension. Object of the research: The influence of the stabilizer on the stability and quality of sulphur suspension. During the research, 8 experimental extemporaneous sulphur suspensions were prepared using different stabilizers and their concentrations: methylcellulose of 0.5, 1.0, 1.5 and 2.0 % concentration, tveen 80, aerosil, glycerol and medical soap. The suspensions were kept in two different conditions: in temperatures of 4oC and 15oC - 20oC. Their organoleptic qualities (colour, odour, turbidity/transparency) were assessed at the start of the study, when the suspensions have just been made, and 28 days later. Sedimentation: estimating the precipitated particles in volume units (ml) and calculating the sediment volume F according to the formula, expressed as a percentage and evaluated every 12 hours, every day at the same time for 6 days and weekly for 6 consecutive weeks. Resuspending: evaluating the time spent resuspending of flocculated extemporaneous sulphur suspensions in seconds, evaluating the resuspending of deflocculated suspension as resuspending, resuspending with difficulty, non-resuspending, tested after 1 - 6 days and after 1 - 6 weeks while standing without moving them. The studies showed that all suspensions were turbid both at the beginning and at the end of the study, the colour and odour remained unchanged, except for suspension S-5, which failed to resuspend. When evaluating sedimentation under different storage conditions, 4°C is a more suitable storage condition for methylcellulose suspensions. After evaluation of sedimentation results, it has been determined that methylcellulose of 1.5% concentration is the most suitable stabilizing agent for stabilizing the extemporaneous sulphur suspension. Its sedimentation began only after two weeks of study and after 6 weeks of evaluation, its results ranged between 94% and 98%. Suspension S-8, where medical soap has been chosen for stabilization, was assessed as the most unstable dispersion system, although under natural conditions during the first observation hours it was slower than 4°C but at the end of the study there was no significant difference, F = 20% and 22%. Flocculated suspension resuspended quickly and easily. The research showed fairly good results when methylcellulose was used as the stabilizer. For manufacturing pharmacies, it is recommended to use methylcellulose at a concentration of 1.5% for stabilization of the extemporaneous sulphur suspension while producing the product.

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