Pagrindo, pagalbinių medžiagų ir gamybos būdo įtaka paracetamolio atpalaidavimui iš ekstemporalių žvakučių

Gaidamavičiūtė, Indrė

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dc.contributor.author	Gaidamavičiūtė, Indrė
dc.date.accessioned	2019-01-21T08:02:20Z
dc.date.available	2019-01-21T08:02:20Z
dc.date.issued	2018
dc.identifier.uri	http://dspace.kaunokolegija.lt//handle/123456789/277
dc.description	Relevancy: Belniak and other, (2017) assume, that the rectal way of drug use is beneficial as it can help to prevent liver damage, reduce the side effects of gastrointestinal tract and prevent undesirable effects of food in the absorption of drugs. According to Shegokar and Singh (2012), paracetamol is less toxic and therefore common enough in the list of human medicines. The properties of the excipients may influence the release of the drug from the suppositories and also impact the release rate. According to Ilomuanya and other, (2012), the results of the in vitro study revealed that the hydrophilic-based suppositories exhibited the best releasing properties. Šlekienė (2010) states that the need for extemporal drugs usually increases as patients consider that some medicines can not be replaced by an industrially manufactured drug, and moreover they are cheaper. Objective of the work: To disclose the effect of the substrate, excipients, production method on the release of paracetamol from extemporaneously produced hydrophobic and hydrophilic rectal suppositories by in vitro biopharmaceutical study. Tasks and methods of the work: Substantiate theoretically the rectal suppositories as the form of the drug and the pharmaceutical factors that influence the absorption of medicinal substances from the suppositories. Determine the effect of suppository substrates, excipients and production methods on paracetamol release from rectal suppositories. Evaluate the breakdown time of the paracetamol suppositories under test. Results and conclusions of the research: After having analyzed the results, it was determined that the method of production of suppositories, the excipients, the substrate have influence upon the regularity and quality of their form. It was also found out that paracetamol was most rapidly released from suppositories produced by scrolling. In the baseline (substrate) - choice study, it was discovered that paracetamol is most rapidly released from suppositories with the hydrophilic substrates. Excipients: beeswax and aerosil slow the release of paracetamol from suppositories. After having performed the test on the breakdown time dependence upon the excipients and the substrate, it became clear that the molded suppositories breakdown faster than the scrolled ones. Suppositories with excipient increased the breakdown time of the beeswax by 4.5 times more than that of suppositories without beeswax. Suppositories with excipients – aerosil – did not breakdown, but a soft suppository-shaped matrix remained. Recommendations: It is recommended to continue with the test while using other shapes of suppositories: egg-shaped, sphere-shaped, stick-shaped. It is also important to evaluate the industrial production suppositories, while performing the biopharmaceutical in vitro study, also the study of breakdown and organoleptic properties.	en
dc.description.abstract	Baigiamajame darbe buvo išsiaiškinta nuo ko priklauso žvakučių kokybė, veiksmingumas, taisyklinga forma. Atlikus biofarmacinį tyrimą in vitro išsiaiškinta kaip pagrindas, pagalbinės medžiagos ir gamybos būdas turi įtakos paracetamolio atpalaidavimui iš ektemporalių žvakučių. Išnagrinėjus mokslinę literatūrą ir atlikus tyrimo analize buvo pateiktos išvados. Darbą sudaro įvadas, 2 skyriai, išvados, rekomendacijos, literatūros sąrašas bei priedai. Darbo apimtis 40 psl.	en_US
dc.language.iso	other	en_US
dc.subject	Paracetamolis, atpalaidavimas, ekstemporalios žvakutės	en_US
dc.title	Pagrindo, pagalbinių medžiagų ir gamybos būdo įtaka paracetamolio atpalaidavimui iš ekstemporalių žvakučių	en_US
dc.title.alternative	The Impact of Base, Excipients and Production Method on the Release of Paracetamol from Extemporaneous Suppositories	en_US
dc.type	Other	en_US